Abstract
Osteoprotegerin, RANK (Receptor Activator of Nuclear factor kappa B) and RANKL (Receptor Activator of Nuclear faktor kappa B ligand) became the aim of intensive research. RANK is considered as a hematopoietic surface receptor controlling osteoclastogenesis and calcium metabolism. RANKL may promote osteoresorption by induction of cathepsin K gene expression. The present paper summarizes the most significant data in osteoprotegerin, RANK and RANKL problems obtained.
Highlights
In the membrane of cells of osteoclast line and in dendritic cells, there is a protein crucial for all calciumtropic hormones and proresorptive cytokines to increase calcemia and multiplication of osteoclasts in the bone. This protein was identified as RANK (Receptor Activator of Nuclear factor Kappa B)[10]
It was identified as RANKL (RANK ligand); it may promote osteoresorption by induction of cathepsin K gene expression[10, 30]
RANKL and its inhibitor osteoprotegerin are decisive for differentiation and osteoresorption function of the osteoclast so that they became the aim of intensive research
Summary
In the membrane of cells of osteoclast line and in dendritic cells, there is a protein crucial for all calciumtropic hormones and proresorptive cytokines to increase calcemia and multiplication of osteoclasts in the bone. RANKL binds on receptors on the surface of preosteoclasts and stimulates their differentiation into active osteoclasts, resulting in osteoresorption.
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