Abstract
Objective: Serum level of osteoprotegerin (OPG) has been suggested to be associated with osteoporosis, early coronary artery disease and coronary calcification. However, there was little data regarding the relation of the coronary artery disease and calcification with OPG gene mutation. Methods and results: Four hundred and thirty four patients referred for coronary angiography due to their chest pain were enrolled. All the patients have undergone coronary angiography and were investigated for their genetic mutations with regard to four genes: A163G, G209A, T245G, T950C of OPG gene.
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