Osteoporotic Bone Recovery by a Highly Bone-Inductive Calcium Phosphate Polymer-Induced Liquid-Precursor.

Shasha Yao,Ruikang Tang,Nico A J M Sommerdijk,Changyu Shao,Zhao Mu,Yangwu Chen,Yifei Xu,Xianfeng Lin,Pengcheng Qiu,Biao Jin

doi:10.1002/advs.201900683

Abstract

Osteoporosis is an incurable chronic disease characterized by a lack of mineral mass in the bones. Here, the full recovery of osteoporotic bone is achieved by using a calcium phosphate polymer‐induced liquid‐precursor (CaP‐PILP). This free‐flowing CaP‐PILP material displays excellent bone inductivity and is able to readily penetrate into collagen fibrils and form intrafibrillar hydroxyapatite crystals oriented along the c‐axis. This ability is attributed to the microstructure of the material, which consists of homogeneously distributed ultrasmall (≈1 nm) amorphous calcium phosphate clusters. In vitro study shows the strong affinity of CaP‐PILP to osteoporotic bone, which can be uniformly distributed throughout the bone tissue to significantly increase the bone density. In vivo experiments show that the repaired bones exhibit satisfactory mechanical performance comparable with normal ones, following a promising treatment of osteoporosis by using CaP‐PILP. The discovery provides insight into the structure and property of biological nanocluster materials and their potential for hard tissue repair.

Highlights

Osteoporosis is an incurable chronic disease characterized by a lack of mineral worldwide bone disease, characterized by a lack of HAP in bone and an associated mass in the bones
We demonstrate that the full recovery of osteoporotic bone can be achieved using a free-flowing calcium phosphate polymer-induced liquid-precursor (CaP-PILP) material
Similar to the in vitro experiments, elemental mapping and SAED revealed that the osteoporotic bone and phosphatebuffered saline (PBS) recovered bone showed a strongly reduced mineral content (Figure S11a,b, Supporting Information), while the CaP-PILP recovered bone showed the formation of HAP crystals with their c-axis aligned along the collagen fibrils, similar to that in healthy bone (Figure S11c,d, Supporting Information)

Summary

Introduction

Osteoporosis is an incurable chronic disease characterized by a lack of mineral worldwide bone disease, characterized by a lack of HAP in bone and an associated mass in the bones. The quantitative analysis showed that the optical density (OD) value of the CaP-PILP group was ≈2.0, 1.5, and 20.0 times that of the HAP, ACP, and blank groups, respectively (Figure S5n, Supporting Information).

Objectives

Results

Conclusion