Abstract
Weanling rats develop osteoporosis on a high protein pyridoxine-deficient diet. Urinary o-phosphoethanolamine (OPE) levels are elevated in deficient animals and there is decrease in several hepatic enzymes which require pyridoxal phosphate as cofactor, including OPE phospholyase, an enzyme which degrades OPE. Serum alkaline phosphatase levels do not differ from control animals. Osteoporotic bone disease in the pyridoxine-deficient rat may be responsible in part for the growth failure in these animals, and may be related to the bone disease seen in some human metabolic disorders.
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