Abstract
Osteogenesis imperfecta (OI) is a kind of genetic osteoporosis, whose clinical severities vary from patients to patients. In type I OI, some patients appear normal without investigating bone mineral density (BMD) by DXA. In severe OI children, pamidronate infusion therapy is effective, however it is still uncertain when to stop the pamidronate therapy without having the problems of bone fracture healing. Also, the appropriate therapy for adult and post-menopoause OI patients remains to be clarified in future.
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