Osteoporosis in Сhildren with Itsenko — Cushing Disease: Etiology, Pathogenesis, Diagnosis

M.O Ryznychuk,L.Yu Khlunovska,M.I Kostiv,T.M Kretsu,V.P Dmitruk

doi:10.22141/2224-0721.2.74.2016.70965

Abstract

The review describes the etiology, pathogenetic mechanisms of osteoporosis in children with Itsenko — Cushing syndrome. The new methods for the diagnosis of osteoporosis in children were also analyzed.

Highlights

Itsenko — Cushing disease brings together a large group of signs and progressive symptoms wich reflect the prolonged and excessive influence of glucocorticoids on the tissue
Steroid osteoporosis that develops as a result of pathologic effect on bone of the excessive amount of endogenous glucocorticosteroids (GCS), appears in 95 %, and fractures of the spine — in 40 % of patients [3]
GCS have catabolic effects on skeletal muscle, this, in turn, reduces bone mineralization and increases the risk of osteoporosis according to mechanostatic theory [2, 20]

Summary

Introduction

Itsenko — Cushing disease (hypercorticoidism) brings together a large group of signs and progressive symptoms wich reflect the prolonged and excessive influence of glucocorticoids on the tissue. Steroid osteoporosis that develops as a result of pathologic effect on bone of the excessive amount of endogenous glucocorticosteroids (GCS), appears in 95 %, and fractures of the spine — in 40 % of patients [3]. GCS reduce the number of osteoclasts in bone tissue and decrease their functional activity.

Results

Conclusion