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Abstract
The review describes the etiology, pathogenetic mechanisms of osteoporosis in children with Itsenko — Cushing syndrome. The new methods for the diagnosis of osteoporosis in children were also analyzed.
Highlights
Itsenko — Cushing disease brings together a large group of signs and progressive symptoms wich reflect the prolonged and excessive influence of glucocorticoids on the tissue
Steroid osteoporosis that develops as a result of pathologic effect on bone of the excessive amount of endogenous glucocorticosteroids (GCS), appears in 95 %, and fractures of the spine — in 40 % of patients [3]
GCS have catabolic effects on skeletal muscle, this, in turn, reduces bone mineralization and increases the risk of osteoporosis according to mechanostatic theory [2, 20]
Summary
Itsenko — Cushing disease (hypercorticoidism) brings together a large group of signs and progressive symptoms wich reflect the prolonged and excessive influence of glucocorticoids on the tissue. Steroid osteoporosis that develops as a result of pathologic effect on bone of the excessive amount of endogenous glucocorticosteroids (GCS), appears in 95 %, and fractures of the spine — in 40 % of patients [3]. GCS reduce the number of osteoclasts in bone tissue and decrease their functional activity.
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