Osteopontin Serum Concentration and Metabolic Syndrome in Male Psoriatic Patients.

Joanna Bartosińska,Dorota Raczkiewicz,Jarosław Bartosiński,Jakub Kosiński,Grażyna Chodorowska,Dorota Krasowska,Katarzyna Chyl-Surdacka,Małgorzata Kowal,Beata Sarecka-Hujar,Joanna Przepiórka-Kosińska

doi:10.3390/jcm10040755

Abstract

Psoriasis (Ps) is an immune-mediated inflammatory skin disease that is widely associated with the clinical features of metabolic syndrome (MetS), including hypertension, abdominal obesity, insulin resistance, type 2 diabetes and dyslipidemia. Osteopontin (OPN), a multifunctional protein involved in the modulation of inflammatory processes, may contribute to the development of atherosclerosis and MetS. Therefore, the aim of the study was the assessment of the correlation between OPN concentration in the peripheral blood and the presence of MetS as well as its particular components in the Ps patients. The study comprised 107 male Ps patients (50 patients with MetS and 57 without MetS) and 38 healthy volunteers (HVs). The concentration of OPN in serum was determined using enzyme-linked immunosorbent assay (ELISA) method. Fasting blood glucose and lipid profile components: total cholesterol (total CHOL), high-density lipoprotein cholesterol (HDL-CHOL), low-density lipoprotein cholesterol (LDL-CHOL), triglycerides (TG) were examined. Ps patients with MetS had significantly higher obesity, systolic blood pressure, TG, CHOL/HDL, LDL/HDL and TG/HDL ratios than Ps patients without MetS. OPN serum concentration was significantly higher in the Ps patients than in the HVs (p = 0.022) but not significantly different between the Ps patients with and without MetS (p = 0.275). OPN serum concentration in Ps patients correlated negatively with total CHOL (p = 0.004) and TG (p = 0.009). OPN is increased in Ps patients and may serve as a biomarker of some lipid abnormalities in them.

Highlights

Psoriasis (Ps) is a chronic inflammatory skin disease of complex pathogenesis with genetic predisposition, environmental factors and immunological disturbances
Chronic inflammation, which is the essence of pathophysiological phenomena in Ps, is a factor predisposing these patients to the occurrence of systemic disorders, including diabetes, hypertension, lipid disorders and cardiovascular diseases (CVDs)
Numerous inflammatory mediators produced by various cells, including Th—Th1, Th17, Th22 subpopulations, which produce such cytokines as tumor necrosis factor α (TNF-α), interleukin 17 (IL-17), IL-22, participate in the formation of psoriatic plaques as well as in the development of atherosclerosis and CVDs [1,2]

Summary

Introduction

Psoriasis (Ps) is a chronic inflammatory skin disease of complex pathogenesis with genetic predisposition, environmental factors and immunological disturbances. Chronic inflammation, which is the essence of pathophysiological phenomena in Ps, is a factor predisposing these patients to the occurrence of systemic disorders, including diabetes, hypertension, lipid disorders and cardiovascular diseases (CVDs). It has been demonstrated that with the increase in body mass index (BMI), the risk of Ps increases [4], and the increased production of TNF-α in obese patients shows a positive correlation with the amount of IL-17 produced [5]. Both obesity and systemic inflammation contribute to the development of insulin resistance and type 2 diabetes [4]. Patients with Ps have an increased risk of dyslipidemia, i.e., elevated triglycerides, LDL (low-density lipoprotein) cholesterol, VLDL (very-low-density lipoprotein) and decreased HDL (high-density lipoprotein) cholesterol [2,3,4]

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