Abstract
Objective: Osteopontin (OPN) is a glycoprotein of the extracellular matrix and interacts with its receptor integrin ß3, which we previously found to be expressed in benign and malignant endocrine tissues of the utero-placental system, and which were shown to mediate cellular migration and invasion and to contribute to tumorigenesis in several types of cancers. Recently, expression profiling of adrenal neoplasms revealed OPN mRNA to be expressed in these tumors. The present study was designed to analyze the expression of OPN protein in normal and tumorous adrenal tissues.
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