Abstract
Purpose: The pathophysiology of early stage knee osteoarthritis (OA) has recently become one of the hot topics and has been paid particular attention in this field. A population based observational study, in which 710 people aged >50 years of age (62.3 years of age in average) who had no radiographic evidence of knee OA [Kellgren-Lawrence (KL) grade 0] and underwent MRI of the knee, showed that the prevalence of any abnormality on MRI was 89% overall and osteophytes, but no cartilage lesion, were the most common abnormality (74%) among all participants (BMJ 2012).Osteophytes are formed by a similar process occured in the endochondral ossification and are composed of not only bone part but also cartilage part at their edge.
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