Abstract
The aim of the present paper was to present the association between mandibular osteonecrosis and use of bisphosphonates for therapeutic purposes.Bisphosphonates are drugs used for the treatment of primary and secondary bone disorders. They are mainly used for local and general osteoporosis treatment, metabolic bone diseases, soft tissue calcification as well as hypercalcemia occurrence, among others. They can also act as antineoplasic agents through the inhibition of activation of cancer-linked proteins. In recent years, bisphosphonates have been used to prevent post-menopause osteoporosis, since they enhance mineral density increase in bone and therefore contribute to a decrease in fractures. The clinical case here presented is that of a 61 year old female patient with previous history of breast cancer and ongoing 3 year bisphosphonate intake. The patient presented asymptomatic, spontaneous bone exposition. Surgical and medical handling of the case are presented, as well as its evolution.
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