Abstract
Beta-tricalcium phosphate (β-TCP) has been used for bone regeneration with satisfactory clinical results in accelerating bone formation. However, little is known about the molecular mechanisms enhancing the bone formation by β-TCP. To understand this mechanism, β-TCP was implanted into bone defects of the mandible in beagles and gene expression profiles were examined using DNA microarray technology. β-TCP altered many gene expressions ; among those genes, a significantly higher mRNA level of osteomodulin (OMD) was observed. The enhanced OMD gene expression level was successfully confirmed by reverse transcription-polymerase chain reaction and real-time polymerase chain reaction. Because OMD is a potent regulator of mesenchymal cell function of wound healing and osteogenic differentiation, the enhancement of the OMD gene expression by β-TCP may be an important mechanism in accelerating bone formation.
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