Osteoinductive potential of bone scaffolds developed from FYR Bioceramic (a material of emitting high performance far-infrared ray irradiation)

Abstract

Background: Autogenous bone has been considered the golden standard for bone replacement procedures in maxillofacial surgery. Synthetic inert bioceramics are currently used as an alternative to autogenous bone graft. New developed type of so called FYR type of Bioceramic (FYRTOB) is a material that emits high performance far-infrared rays (4–20 μm), and possess physical, chemical and biological characteristics on irradiation of water: reducing the size of water clusters and weakening of the hydrogen bonds of water molecules and other effects on physical and chemical properties of water). The use of FYRTOB bone substitutes is not noted in the literature. Objectives: The present study examined the osteoinductive potential of effects of FYRTOB using in vivo animal models. Methods: In this study, autogenous milled bone grafts harvested with a trephine from Wistar rats and a novel alloplastic FYRTOB were implanted into bilateral muscle pouches (25 mg per pouch) of 30 Wistar rats and analysed histologically (at three and six weeks postoperatively) for their ability to induce new ectopic bone formation around grafted material. A semi-quantitative osteoinductive score was used to quantify the osteoinductive ability of both bone grafts. Results: The results reveal that the FYRTOB bone graft possessed 2.1 times higher osteoinductive potential in comparison with autogenous bone. Conclusion: These findings suggest that FYRTOB bone grafts have potential for inducing ectopic bone formation. Future clinical testing is necessary to reveal their bone-inducing properties in different clinical scenarios.