Abstract
Background and Objective. Dental stem cell-based tissue engineered constructs are emerging as a promising alternative to autologous bone transfer for treating bone defects. The purpose of this review is to systematically assess the preclinical in vivo and in vitro studies which have evaluated the efficacy of dental stem cells on bone regeneration. Methods. A literature search was conducted in Ovid Medline, Embase, PubMed, and Web of Science up to October 2014. Implantation of dental stem cells in animal models for evaluating bone regeneration and/or in vitro studies demonstrating osteogenic potential of dental stem cells were included. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines were used to ensure the quality of the search. Modified ARRIVE (Animal research: reporting in invivo experiments) and CONSORT (Consolidated reporting of trials) were used to critically analyze the selected studies. Results. From 1914 citations, 207 full-text articles were screened and 137 studies were included in this review. Because of the heterogeneity observed in the studies selected, meta-analysis was not possible. Conclusion. Both in vivo and in vitro studies indicate the potential use of dental stem cells in bone regeneration. However well-designed randomized animal trials are needed before moving into clinical trials.
Highlights
Bone is a multifunctional organ that provides protection, structure, and mechanical support to the body [1]
The purpose of this review was to summarize the role of dental-derived stem cells and their effects on the osteogenic differentiation potential and bone regeneration
CONSORT guidelines are designed to be used in randomized controlled trials (RCTs), we found it reasonable to apply these guidelines to in vitro studies to emphasize the quality and importance of avoiding bias in reporting or in research, because all phases of research process are interlinked [26, 28, 32]
Summary
Bone is a multifunctional organ that provides protection, structure, and mechanical support to the body [1]. Autologous bone grafting has been considered as a “gold standard” because it possesses osteogenesis (osteoprogenitor cells), osteoinduction (BMPs, growth factors), and osteoconduction (scaffold) [7]. Limitations such as a limited supply, resorption, donor site morbidity, deformity, chronic infection, and rejection demand other alternative treatment approaches [7, 8]. The purpose of this review is to systematically assess the preclinical in vivo and in vitro studies which have evaluated the efficacy of dental stem cells on bone regeneration. Both in vivo and in vitro studies indicate the potential use of dental stem cells in bone regeneration. Welldesigned randomized animal trials are needed before moving into clinical trials
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
