Abstract
The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed.
Highlights
Studies have shown that a range of therapeutic effects of various herbal medicines can be identified [1,2,3,4]
In the present review article, the main aim was to focus on curcumin capacities in the osteogenic differentiation of mesenchymal stem cells (MSCs) and evaluation of its various molecular mechanisms
69 nm 170 nm review of recent studies demonstrated that AMPK regulation and activating the Wnt signaling pathway are main mechanisms of curcumin for suppression of MSCs from adipogenic differentiation
Summary
Studies have shown that a range of therapeutic effects of various herbal medicines can be identified [1,2,3,4]. Curcumin (diferuloylmethane) as a bioactive hydrophobic polyphenolic ingredient is obtained from Curcuma longa (turmeric) rhizome It received significant attentions as a medicinal plant due to its unique therapeutic benefits including antipathogenic, antioxidant, anti-inflammation, antiangiogenic, anticancer, and antidiabetic effects, as treatment for central nervous system and cardiovascular disorders, in skin diseases and the cosmetic industry, lung diseases, antiatherosclerotic, ophthalmic, cystic fibrosis and osteoporosis, beta-thalassemia, etc. We highlighted the cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail
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