Abstract
A novel web-like structured, biodegradable, hybrid sheet has been developed for bone tissue engi- neering by preparing knitted poly(DL-lactic-co-glycolic acid) (PLGA) sheets with collagen microsponges in their openings. The PLGA skeleton facilitated formation of the hybrid sheets into desired shapes, and the collagen microsponges in the pores of the PLGA sheet promoted cell adhesion and uniform cell distribution throughout the sheet. A large number of osteoblasts established from marrow stroma adhered to the scaffolds and generated the desired shaped bone in combination with this novel sheets. The web-like structured novel sheet show promise for use as a tool for custom-shaped bone regeneration in basic research on osteogenesis and for the development of therapeutic applications.
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