Abstract
Background: Due to the lack of data on bone-to-graft contact (BGC) over time in the various regions within the subantral space of the augmented sinus floor, the present study aimed to evaluate the osteoconductivity of deproteinized bovine bone mineral (DBBM) with granules of different sizes applied in maxillary sinus floor elevation. Methods: A maxillary sinus augmentation was performed bilaterally in 18 rabbits using DBBM with particle dimensions of either 0.125–1.0 mm or 1–2 mm. The antrostomy was covered using a collagen barrier. The animals were euthanized in groups of six after 2, 4, and 8 weeks of healing. MicroCT and histological analyses were performed. Results: After 2 weeks of healing, BGC was 10.9% and 11.9% for the small and large granule sites, respectively. After 8 weeks of healing, the BGC increased to 65% and 62% at the small and large granule sites, respectively. The highest values were located close to the bony walls and the bony window. New bone content developed between 2 and 8 weeks from 7.0% to 27.6% and from 6.1% to 27.6% at the small and large granule sites, respectively. Conclusions: Similar outcomes in osteoconductivity and bone formation were found at both small and large DBBM granule sites.
Highlights
When the bone volume in the posterior regions of the maxilla does not allow the installation of implants of adequate length, a sinus floor augmentation procedure is often applied to increase the height of available bone
Xenografts of various particle sizes are widely used as filler materials [7,8,9,10]
The present experiment aimed to evaluate the osteoconductivity of deproteinized bovine bone mineral (DBBM) with granules of different sizes used for maxillary sinus floor augmentation
Summary
Due to the tendency of the sinuses to re-pneumatize over time after the elevation of the Schneiderian membrane [1,2,3,4,5], various biomaterials have been applied, aiming to counteract that re-pneumatization [6]. Xenografts of various particle sizes are widely used as filler materials [7,8,9,10]. Depending on their structure, the particles of xenografts will either be resorbed over time at different rates or embedded into newly formed tissues [11,12,13,14]. Deproteinized bovine bone mineral (DBBM) has been applied in several clinical [7,8,15,16] and experimental studies [11,17,18,19], showing high volumetric stability compared with other biomaterials
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