Osteochondral lesions of the talar dome in the athlete: what evidence leads to which treatment

Is the anterolateral ligament the smoking gun to explain rotational knee laxity or just vaporware?

Common Musculoskeletal Disorders in Women

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Bone–cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies

Locating the rotator cable during subacromial arthroscopy: bursal- and articular-sided anatomy.

Foot Care

A Call for More Studies Evaluating Posttraumatic Knee Osteoarthritis in Patients Undergoing Combined Anterior Cruciate Ligament Reconstruction and Lateral Extra-Articular Stabilization

Static patellofemoral alignment in anterior cruciate ligament deficient knees; a retrospective analysis with magnetic resonance imaging

Suture Bridge Fixation for Tibial Eminence Fractures

Gene transfer approaches to the healing of bone and cartilage.

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The recent paper “Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity”

Superior Capsular Reconstruction—Technical Marvel or Fading Fashion?

Engineering Stem and Stromal Cell Therapies for Musculoskeletal Tissue Repair.

Caffeine is one of the most widely used substances as recreational drug for performance-enhancement in sport, underpinned by a strong evidence base. Although the effects of caffeine are widely investigated within the scope of performance physiology, the molecular effects of caffeine within skeletal muscle remain unclear. Evidence from invitro and invivo models suggest that caffeine regulates the glucose metabolism in the skeletal muscle. Moreover, caffeine seems to stimulate CaMKII, PPARδ/β, AMPK and PGC1α, classical markers of exercise-adaptations, including mitochondrial biogenesis and mitochondrial content. This review summarizes evidence to suggest caffeine-effects within skeletal muscle fibers, focusing on the putative role of caffeine on mitochondrial biogenesis to explore whether caffeine supplementation might be a strategy to enhance mitochondrial biogenesis.