Abstract
SummaryExaminations of bone marrow samples aspirated from 21 infants with symptoms of rickets showed a significant increase in the number of osteoblasts and osteoclasts as compared with control material.The osteoblasts showed marked positive alkaline phosphatase staining reaction, while the osteoclasts‐and osteoblasts to a lesser extent‐showed positive staining reaction of acid phosphatase.A significant correlation could be established between number of osteoblasts in bone marrow smers and level of serum alkaline phosphatase. Previous reports of similar marrow findings in diseases characterized by bone destruction and compensatory bone repair are reviewed. The mechanisms and the possible significance of such findings are evaluated.
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