Abstract
Osteosarcoma most commonly arises in the long bones of the skeleton, and rarely develops in the bones of the foot. We describe a patient who presented with left foot pain, whose radiographic evaluation revealed a lytic destructive mass in the cuboid bone. A biopsy showed an osteoblastoma-like variant of osteosarcoma and the patient was treated with preoperative chemotherapy and amputation. Osteosarcoma of the foot is uncommon and the literature reveals that it is often associated with a delay in diagnosis.
Highlights
Osteosarcoma is a malignant neoplasm of bone in which tumor cells produce neoplastic bone matrix [1]
Initial diagnostic tests suggested that the lesion was benign, an open biopsy revealed a high grade osteoblastoma-like variant of osteosarcoma, which to our knowledge is the first case published involving the cuboid bone
Osteosarcoma is a malignant neoplasm with a spectrum of biological potential most are high grade and behave in an aggressive fashion
Summary
Osteosarcoma is a malignant neoplasm of bone in which tumor cells produce neoplastic bone matrix [1]. Initial diagnostic tests suggested that the lesion was benign, an open biopsy revealed a high grade osteoblastoma-like variant of osteosarcoma, which to our knowledge is the first case published involving the cuboid bone. Case Report A 32 year old man presented to an outside hospital with a one month history of left foot pain. Based on the clinical and radiographic findings, the lesion was thought to represent a benign, but potentially locally aggressive neoplasm such as giant cell tumor of bone. The neoplastic osteoblasts grew in solid aggregates, were cytologically malignant with nuclear enlargement, coarse chromatin, and hyperchromasia, demonstrated many mitoses and produced coarse lace-like neoplastic bone typical of a high grade osteosarcoma (figure 6). No vascular invasion was identified and all margins of resection were widely negative
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