Abstract
Purpose: Osseous metaplasia occurring in colorectal polyps is rare. The incidence, severity, morbidity, and mortality are poorly documented in the literature. We describe the first case of osseous metaplasia occurring in a hyperplastic polyp of the sigmoid colon. The exact mechanism of bone formation developing within gastrointestinal neoplasia is unknown but is likely due to mesenchymal precursor cells transforming into osteoblasts capable of osteoid production. Heterotopic bone formation can occur in both benign and malignant tumors without the preoccurance of necrosis, inflammation, extracellular mucin, calcification and/or increased stromal vascularity. Eleven cases have now been described in the literature. Osseous metaplasia is predominately found in left sided lesions (64% of cases) including the rectum and sigmoid. Isolated cases have been found in the ileum, jejunum, stomach, and esophagus. Osseous Metaplasia is a rare finding in colorectal polyps with undetermined clinical significance.Figure: Osseous metaplasia within a hyperplastic sigmoid polyp.
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