Osseointegration of Ti6Al4V scaffolds produced by selective laser melting (SLM) after surface treatment

Abstract

Event Abstract Back to Event Osseointegration of Ti6Al4V scaffolds produced by selective laser melting (SLM) after surface treatment Ana Paula Rosifini Alves Claro1, Jaqueline Bastos1, Liliane Oliveira1, Alessandra Machado2, Ricardo Lopes2 and André Jardini3 1 UNESP - Guaratinguetá Campus, Materials and Technology, Brazil 2 COPPE - RJ, Nuclear Instrumentation Lab, Brazil 3 Unicamp,School of Chemical Engineering, Brazil The purpose of this in vivo study was to evaluate the osseointegration of the Ti6Al4V porous scaffolds in rats after surface treatment. SLM (Direct Selective Laser Melting) was used to produce cylindrical samples with 2.5 mm of diameter and 2 mm of height to the predefined CAD models. After SLM processing, samples were treated in tubular furnace at 1000 °C for 12 hours and they were divided into three groups according surface treatment: alkaline; biomimetic and biomimetic plus sodium alendronate. Scaffolds without surface treatment were used as control group. For alkaline treatment, samples were immersed in NaOH solution (10 mMol/L) at 60 °C during 24 hours. After drying into oven (24 hours) were treated at 300 °C for 1 hour. Biomimetic treatment consisted in the immersion of the samples in SBF (Simulated Body Solution) during 5 days after alkaline treatment. For the third group, samples were immersed during 3 days in solution formed by SBF (Simulated Body Fluid) plus sodium alendronate after biomimetic treatment. Surfaces of the samples were evaluated for each treatment by using X-rays analysis and Scanning Electron Microscopy (SEM). In vivo study was performed in rats to evaluate the influence of surface treatment in osseointegration of the scaffolds. After 30 days, rats were sacrificed and their tibias were scanned by using μCT system. Figure 1 shows SEM images of the scaffolds after surface treatment in the solution formed by SBF plus sodium alendronate. It can be observed that the recovering of the surface with the incorporation of the drug and apatite. These results were confirmed by using X-rays analysis. Micro CT results showed that all treatments exhibited positive effect. However, the better bone volume was verified to scaffolds after immersion in SBF plus sodium alendronate. The authors would like to thank Dra Veronica C. V. Martins and Dr Rodrigo Neto Ferreira ( Fundação Educacional Dom André Arcoverde, Valença, RJ) for excellent surgical assistance. Keywords: Tissue Engineering, Scaffold, Surface modification, Rapid prototyping Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Surface and interfacial characterization Citation: Rosifini Alves Claro A, Bastos J, Oliveira L, Machado A, Lopes R and Jardini A (2016). Osseointegration of Ti6Al4V scaffolds produced by selective laser melting (SLM) after surface treatment. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.00706 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ana Paula Rosifini Alves Claro Jaqueline Bastos Liliane Oliveira Alessandra Machado Ricardo Lopes André Jardini Google Ana Paula Rosifini Alves Claro Jaqueline Bastos Liliane Oliveira Alessandra Machado Ricardo Lopes André Jardini Google Scholar Ana Paula Rosifini Alves Claro Jaqueline Bastos Liliane Oliveira Alessandra Machado Ricardo Lopes André Jardini PubMed Ana Paula Rosifini Alves Claro Jaqueline Bastos Liliane Oliveira Alessandra Machado Ricardo Lopes André Jardini Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.