Abstract
BackgroundIn this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed.Methods The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 700 °C for 1 h and the influence of local administration of growth hormone (GH) in osteoporotic female rabbits after 15 and 30 days of implantation have been studied. Bone response was analysed through densitometric and histomorphometric studies. Characterization of the surface was provided by scanning electron microscopy.ResultsThe oxidation treatment promotes the formation of an oxide scale grown on the Ti6Al4V implants that alters the nanoroughness of the surface. Bone mineral density (BMD) increases from 0.347 ± 0.014 (commercial) to 0.383 ± 0.012 g cm−2 (modified), and bone-to-implant contact (BIC) goes from 48.01 ± 14.78 (commercial) to 55.37 ± 15.31 (modified) after 30 days of implantation.ConclusionsThe oxidation treatment on the Ti6Al4V dental implants enhances the early bone formation at the longest periods of implantation. No significant differences in the BMD and BIC results in healthy and osteoporotic rabbits were revealed with respect to the local administration of GH in the implantation site.
Highlights
In this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed
The chemical analysis performed by energy dispersive X-ray (EDX) of a representative area (Table 1) shows the characteristics peaks of Ti, Al and V, together with some proportion of Ca and P
It is unavoidable that the blasting particles induces abrasive pollution on the surface, giving rise to a surface modification in the final roughness and in the chemical composition, that influences the physicochemical properties of the blasted surfaces [25]
Summary
In those cases where there is a delay in the physiological mechanisms of bone repair, either by aging or due to problems of osteoporosis, the solution must be taken by means of external substances that stimulate the bone metabolism. Studies carried out by Becker et al [16] revealed that local application of diverse growth factors (IGF-I and PDGF) induce the statistical increase in bone repair and the increase of bone density, around Ti implants, compared with the control group. The administration is able to increase up to 400 % the mechanical properties with respect to the control group [17, 18], stimulate the osteoblast activity and enhance the bone neoformationa around implants [14]
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