Abstract
ABSTRACT Objective The objective of this experimental study was to evaluate, through bone densitometry, the performance of two factors that may influence the osseointegration process: nicotine and superficial texturization of the implants. Methods Nineteen New Zealand rabbits (Oryctolagus cuniculus) were randomly distributed in two groups (test and control), in which 38 implants were placed. 19 machined implants (flat) 3.75 mm of diameter by 6.0 mm length were placed at the right tibia of the animals and, at the left tibia, 19 anodized implants (Vulcano(r)) with the same dimensions. Subcutaneous injections of nicotine 3ml/day/kg, three times a day were administered in group, group control also received, three times a day, subcutaneous solution of NaCl (3ml/day/kg), for 8 weeks. After this period, the densitometry analysis was performed. Results Considering the optical density (pixels), there were no statistical significant differences between the types of implants (p = 0.135) as well as between groups (p=0.590). Conclusion The nicotine inside the experimental conditions used in this study and the superficial texturization of the implants indicated that they were not influencing bone density.
Highlights
The success of the osseointegration has been constantly associated with bone density quality that can be impaired, among other causes, due to smoking
The nicotine inside the experimental conditions used in this study and the superficial texturization of the implants indicated that they were not influencing bone density
Yuhara et al.[3] associated nicotine with the increase of the calcium ion removal, the production of alkaline phosphatase and the reduction of the osteoclastic activity, whereas Iwaniec et al.[4] did not find any loss of volume, resistance or bone mass with serum concentrations of nicotine which are superior to those that were found in smoking when the exposure of female rats that are growing with nicotine for two or three months
Summary
The success of the osseointegration has been constantly associated with bone density quality that can be impaired, among other causes, due to smoking. Various authors confirmed this deleterious effect in moderate and heavy smoking patients, mainly when implants are placed in their maxilla, with relation to slight and non-smokers[1,2]. Long-term studies demonstrated that implants of titanium of rough surface presented greater bone loss in smokers than in non-smokers, mainly when they were placed in maxilla[7]. Kumar et al.[8] found out that in one period of 18 months the habit of smoking did not play a significant role in obtaining osseointegration with implants of modified surface
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
