Abstract
The purpose of this study is to analyze the prospects for the use of local cryotherapy in bone remodeling. Intense cooling causes a response. To evaluate the effectiveness of cryostimulation of a bone defect in the in vivo model of Wistar rats, through defects 2 mm in diameter were formed. The animals were subjected to 1 and 2 cryotherapy per week. The average local temperature of the skin surface decreased from 28 to 14 C. The decrease in temperature inside the biological tissue near the bone defect was 5.3C. Microcomputer tomography and histological analysis showed that cryotherapy 2 times per week is an effective method. The results showed the promise of using low temperatures in the complex treatment of injuries and bone diseases. This information will be useful for understanding the correlation of the effect and impact of cryostimulation, as well as for the development of treatment protocols, the study allows us to take a step towards the possibility of bone healing using cryostimulation in practice.
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