Abstract
We have previously shown that unstimulated mouse mandibular granular duct cells contain a hyperpolarization-activated Cl<sup>-</sup> conductance having characteristics similar to those of ClC-2 channels. We now show that exposure of the granular duct cells to hypotonic solutions inhibits the hyperpolarization-activated Cl” current whereas exposure to hypertonic solutions causes it to be transiently activated and then inhibited. Like C1C-2 channels in <i>Xenopus </i>oocytes, the hyperpolarization-activated Cl<sup>–</sup> current in mouse granular duct cells is sensitive to osmolality, although its response to osmolality is the reverse of that seen with C1C-2 channels, perhaps due to a difference in the mechanism by which the osmolality signal is transduced to a change in channel activity.
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