Abstract
The encapsulation of payloads in micro- to nano-scale capsules allows protection of the payload from the surrounding environment and control of its release profile. Herein, we program the release of hydrophilic payloads from nanocontainers by co-encapsulating simple inorganic salts for adjusting the osmotic pressure. The latter either leads to a burst release at high concentrations of co-encapsulated salts or a sustained release at lower concentrations. Osmotic pressure causes swelling of the nanocapsule's shell and therefore sustained release profiles can be adjusted by crosslinking it. The approach presented allows for programing the release of payloads by co-encapsulating inexpensive salts inside nanocontainers without the help of stimuli-responsive materials.
Highlights
Osmotic pressure is a crucial phenomenon in nature.[1,2] The cell maintains the concentration of solutes via osmotic pressure[1] and plants rely on it to absorb water and maintain cell rigidity.[2]
The formation of polyurea shells was performed through a polyaddition reaction between the primary amino groups (–NH2) of hydrophilic 1,4-diaminobutane and the isocyanate group (–NCO) of 2,4-toluene diisocyanate (TDI) that occurs at the interface of miniemulsion droplets.[52]
The obtained polyurea NCs were transferred in an aqueous solution of sodium dodecyl sulfate (SDS) (0.3 wt%)
Summary
Osmotic pressure-dependent release profiles of payloads from nanocontainers by Cite this: Nanoscale, 2016, 8, 12998 co-encapsulation of simple salts†. We program the release of hydrophilic payloads from nanocontainers by co-encapsulating simple inorganic salts for adjusting the osmotic pressure. The latter either leads to a burst release at high concentrations of co-encapsulated salts or a sustained release at lower concentrations. Osmotic pressure causes swelling of the nanocapsule’s shell and sustained release profiles can be adjusted by crosslinking it. The approach presented allows for programing the release of payloads by co-encapsulating inexpensive salts inside nanocontainers without the help of stimuli-responsive materials
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
