Abstract
The effect of increasing concentrations of electrolytes and nonelectrolytes on the ATPase activity of rat liver mitochondria was studied. It was found that as the molarity of nonpenetrating solutes was increased above isotonicity the ATPase activity induced by 2,4-dinitrophenol, pentachlorophenol, valinomycin, and gramicidin sharply decreased. The inhibitory effect of nonpenetrating solutes could be released by the addition of permeant salts. It is suggested that the inhibition of ATPase activity by impermeant solutes at high concentrations is due to the loss of water from the matrix space.
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