Abstract
N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymers were detected in the ipsilateral cerebral hemisphere following intracarotid infusion of l-(+)-arabinose (1.8 M) in the rat. The measured cerebrovascular permeability-surface area product (PA) values (× 10 6 s −1) varied from 12.7 to 141.1, the PA value being dependent on the molecular weight average, and chemical characteristics, of the HPMA copolymer preparation used. Higher PA values were observed for HPMA copolymers of lowest molecular weight, and for copolymers containing cationic and hydrophobie substituent groups. Although less than 1% of the administered HPMA copolymer was transferred into the brain (within 10 min), this should be sufficient to permit delivery of a therapeutic dose of anticancer agent.
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