Osmotic Delivery and Release of Lipid-Encapsulated Molecules via Sequential Solution Exchange

Abstract

Passive targeted drug delivery to solid tumors is driven by the permeation of drug carriers into a tumor's interstitial matrix, which is slow and ineffective. This study suggests an $a\phantom{\rule{0}{0ex}}c\phantom{\rule{0}{0ex}}t\phantom{\rule{0}{0ex}}i\phantom{\rule{0}{0ex}}v\phantom{\rule{0}{0ex}}e$ delivery strategy to enhance the permeation of therapeutic molecules into the interstitium. The authors show that, by gradually changing the solutes of the interstitial fluid, liposomes can respond to the change in the chemistry of the surrounding fluid, leading to enhanced transport and controlled release.