Abstract
It is established that very few modern high-quality drugs in the dosage form "Solution for injection" have isoosmotic activity in the range of 280-300 mosmol/l of water. The main part of solutions for injection is hypotonic or hypertonic solutions, which can have osmotic activity in the range of 0 - 4000 mosmol/l of water. The reason for this was that the osmotic activity of drugs is not included in the list of controlled indicators of drugs quality, so it is not subject to control. It is shown that the osmotic activity of drug solutions increases with an increase in the total concentration of all dissolved ingredients present in the solution. It was found that an excessively high concentration of the drug in the solution gives it an excessively large hyperosmotic activity, which can cause a local irritant and cauterizing effect at the injection sites due to dehydration of the cells. Therefore, to exclude post-injection abscesses, it is proposed to dilute the hypertonic drug with water for injection until it is given isotonic activity.
Highlights
Post-injection abscesses still remain an "abandoned" area of research in pharmacy and pharmacology
The results showed that modern "Solution for injection" have concentrations of dissolved ingredients in the range of 0-76% and osmotic activity in the range of 0-4000 mosmol/l of water
It is established that the osmotic activity of the drug solution is greater, the greater the concentration of the dissolved ingredients
Summary
Post-injection abscesses still remain an "abandoned" area of research in pharmacy and pharmacology. Careful observance of aseptic and antiseptic measures does not exclude the appearance of local inflammation, necrosis and abscess in the metas of injections of many drugs. The risk of these iatrogenic complications is especially high if drug solutions with a concentration of ingredients of more than 5% accidentally enter the cellular tissues. One of the causes of post-injection abscesses may be hidden in the solution of the drug itself, namely, in its excessively high concentration. The values of the concentration of dissolved ingredients, osmotic and acid activity in 40 highquality solutions for injection from different pharmacological groups were studied. It is established that the osmotic activity of the drug solution is greater, the greater the concentration of the dissolved ingredients
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