Abstract
BackgroundSensory hypersensitivities are common phenomena in migraine. We examined the role of sensory hypersensitivities on suicidality in patients with migraine.MethodsPatients with migraine (with or without aura) were consecutively recruited from our headache clinic. We asked them if they experienced photophobia, phonophobia, osmophobia, and allodynia during migraine attack. The Mini International Neuropsychiatric Interview was used to diagnose current major depressive disorder (MDD), current generalized anxiety disorder (GAD) and suicidality.ResultsAmong 220 subjects, 25.5 % had current MDD, 17.3 % had current GAD, and 31.8 % had suicidality. Patients with suicidality were more like to have a low household income, chronic migraine (CM), medication overuse headache, high headache intensity, osmophobia, allodynia, high disability, MDD, and GAD than those without suicidality. The strongest risk factor for suicidality by multivariate analyses was osmophobia (adjusted Odds Ratio [AOR] 3.12, 95 % confidence interval [CI] 1.57-6.21, p = 0.001), followed by current MDD (AOR 2.99, 95 % CI 1.33-6.76, p = 0.008), CM (AOR 2.48, 95 % CI 1.21-5.09, p = 0.013), current GAD (AOR 3.11, 95 % CI 1.22-7.91, p = 0.017), and allodynia (AOR 2.72, 95 % CI 1.19-6.21, p = 0.018).ConclusionsOsmophobia and allodynia are critical factors for suicidality in patients with migraine, after controlling for depression, anxiety, and CM.
Highlights
Sensory hypersensitivities are common phenomena in migraine
episodic migraine (EM) was manifested in 95 patients (43.2 %), chronic migraine (CM) in 125 patients (56.8 %), and medication overuse headache (MOH) in 52 patients (23.6 %)
Photophobia, phonophobia, osmophobia, and allodynia were manifested in 104 patients (47.3 %), 140 patients (63.6 %), 108 patients (49.1 %), and 39 patients (17.7 %), respectively
Summary
Sensory hypersensitivities are common phenomena in migraine. We examined the role of sensory hypersensitivities on suicidality in patients with migraine. Migraine with aura has been chosen as a migraine-specific factor for suicide after controlling for age, gender, major depression, and anxiety disorders [1,2,3]. Sensory hypersensitivities such as photophobia, phonophobia, osmophobia, and allodynia were frequently observed in patients with migraine [7,8,9,10,11,12]. We investigated whether sensory hypersensitivities contributed to suicidality in patients with migraine
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