Oscillatory transcriptional activity of cardiac L-type Ca2+ channel

Abstract

Cardiac function shows chronobiological regulation, controlled by both central and endogenous clocks that might be impaired in pathological conditions, in which Ca2+ homeostasis plays a critical role. The L-type calcium channels, whose pore is formed by the Cav1.2 subunit, are the main mediators of Ca2+ influx of ventricular cardiomyocytes participating to cardiac electrical activity, contraction and gene expression. Thus, the study of rhythm in the dynamics of Cav1.2 expression is of importance.