Abstract
Three examples of substances which affect the frequency of the oscillatory reduction of pyridine nucleotides during anaerobic glycolysis in Saccharomyces carlsbergensis are given. Two of them, namely, 2-deoxyglucose and ammonium ions, exert their influence via the intracellular ATP to ADP ratio; the third, fluoride ions, via the activity of the enzyme phosphofructokinase. All three give an increase of the frequency of the oscillatory reductions. These oscillatory reductions are not observed at a high fluoride or ammonium ion concentration. It is concluded that these oscillations do not occur when phosphofructokinase is maintained in an active form, for instance by fluoride ions, or by a low intracellular ATP to ADP ratio, caused by the presence of deoxyglucose or ammonium ions. The effect of the temperature on the frequency of the oscillatory reductions has been investigated.
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