OS039. Early prediction of preeclampsia with maternal parameters,SVEGF-R1, PLGF, Inhibin-A and PAPP-A in general population: Results from the MSPE study

Abstract

complication of pregnancy and cause of maternal and perinatal morbidity and mortality worldwide. The prevalence of chronic hypertension in pregnant women is of 1–5%. The diagnosis is based on the anamnesis data or increase in pressure of up to 140/90 mmHg or more before the 20th week of pregnancy. Objectives: To Establish the clinical significance of pepaBapHo training of women with chronic hypertension of I–II stage II of the degree of risk of CHF 0–I and identify opportunities for drug prevention hypertensive complications in pregnant women. Methods: The Hypertensive disorders in pregnant women divided into three categories: chronic hypertension, gestational hypertension and preeclampsia. The study included 177 women with chronic hypertension of I–II stage II of the degree of risk of chronic heart failure 0–I receive pepaBapHy the preparation of the group (observations) and 100 women with chronic hypertension of I–II stage II of the degree of risk of chronic heart failure 0–I do not receive pre-conceptional training (a comparison group). The age of patients in both groups did not differ, ranging from 18 to 42 years (Me 28 years). Results: The course of pregnancy in the investigated groups complicated: pre-eclampsia (48.02% and 67.0%, respectively, in groups I and II), the threat of termination of pregnancy (45.2% and of 64.0% , respectively), early preeclampsia (28.2% and 35.0% , respectively). Chronic fetal hypoxia of the fetus were observed in 33.9% and 40.0% of women, respectively, delay the development of the fruit – by 16.9% and 20.0%, foetoplacental insufficiency – by 22.6%, 31.0%. Premature births ended 16.9% and 24.0% of pregnancies, respectively. In 100% of the women in the focus groups method of delivery was operation caesarean section in the lower segment of the uterus. The readings from the mother’s side was the failure of a scar on the uterus, narrow pelvis, shoulder of the cervix, detachment normally situated placenta, extra-genital pathology of the mother in the stage of decompensation. From the fruit of the main indications were: acute fetal hypoxia of the fetus, delay the development of the fetus rights violations in the utero-placental basin. Conclusion: Pre-conceptional preparation of women with chronic hypertension, including the treatment of chronic infections with the phenomena of bacterial vaginosis, regulation of violations ofmenstrual function creates a favorable background for the normal course of pregnancy. A careful medical supervision and timely delivery are the key factors in the treatment of arterial hypertension in pregnant women.