Abstract
Abstract Hypertension and Diabetes commonly coexist and have been implicated in deterioration of kidneys, heart and impairment of pancreas. Empagliflozin (Empa), a selective SGLT2 inhibitor, is a new agent for treatment of diabetes via enhancing glucosuria, independent of insulin resistance. This study evaluates Empa's prophylactic beneficial effect on glomerular, cardiac and pancreatic integrity, in CRDH animals. Cohen Rosenthal Diabetic Hypertensive rats (CRDH) were divided into 3 groups: A- Sugar diet (SD) + Empa, B-Sugar Diet + Veh, C-Regular Chow + Veh (Control). Drug was given for 4 months via drinking water at a dose of 10mg/kg/day. Hyperglycemia, hypertension, and additional biochemical parameters were monitored. Immunofluorescence analysis of glomerular nephrin and H&E in pancreas was performed in different experimental groups and their sham controls. To assess left ventricular (LV) remodeling and function, a special small animal echocardiography scanner was used. Blood pressure was significantly (P
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