Abstract
Editor, C orneal transplantation is a highly successful treatment of severe corneal disease. However, because of an increasing shortage of donor corneal tissue, far too many patients whose sight could be restored are denied this procedure. One possible solution to this is xenogeneic sources of donor corneal tissue. Because of its size and availability, the domestic pig has been considered a highly probable source of donor tissue in the setting of solid organ xenotransplantation (Zhong 2007). Furthermore, the dimensions of the porcine cornea allow it to be used as a graft in human transplantation (Faber et al. 2008). Unlike solid organ transplants, the cornea is not a vascularized structure. Corneal endothelium expresses constitutively several membrane-bound proteins that inhibit complement activation. Aqueous humour contains soluble factors that similarly interfere with complement activation (Streilein 2003). This suggests that xenogeneic corneal grafts might not be vulnerable to hyperacute rejection.
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