Abstract
Novel diagnostic techniques have been developed in many research areas using targetable contrast agents with magnetic resonance imaging (MRI) for cancer diagnosis. It is efficient for cancer diagnosis to use MRI with biocompatible targeting moiety and magnetic nanoparticles (MNPs). Thus, we synthesized MNPs using the thermal decomposition method which enables sensitive T2- or T2 Turbo spin echo (TSE) weighted magnetic resonance imaging. And it was coated with Hyaluronic acid (HA). Also, we carried out that gastric cancer cell line (MKN45) which has cancer stem cell properties was injected in a heterotopic mouse model. Then magnetic resonance sequence (T2) for imaging effects and targeting ability were analyzed into MNPs conjugated HA. We noted that the MDA-MB-231 cell which a high-expressed CD44 ligand was showed contrast-enhanced efficiency through magnetic nanoparticles because of combining a lot of HA. As a result of these studies, we conclude that HA-coated magnetic nanoparticles can be effectively used as a novel probe for visualizing Gastric cancer stem cells.
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