Orthostatic myoclonus associated with Caspr2 antibodies.

Abstract

Editors' Note: Critiquing “Orthostatic myoclonus associated with Caspr2 antibodies,” van Gerpen et al. disagree with the diagnosis of orthostatic myoclonus (OM), which, according to their experience, clinically manifests as low-amplitude, tremulous movements, restricted to the legs during standing; appears as semirhythmic bursts lasting less than 50 milliseconds on surface EMG; and lacks prominent action myoclonus in the legs. Govert et al., authors of the case report, defend their diagnosis and explain that OM can be present in the arms and can have subtle action myoclonus. In reference to “Antibiotic-associated encephalopathy,” Dr. Stip argues that there is no clear evidence to link macrolides to altered dopamine levels or NMDA receptor activity and that macrolides have poor CSF …