Abstract
BackgroundThe role of human papillomavirus (HPV) in orthokeratinized odontogenic cysts (OOCs) has rarely been studied. The objective is to describe the clinicopathological findings in a series of OOCs from a Spanish population that were investigated in relation to the possible presence of HPV.MethodsA clinicopathological retrospective analysis followed by a molecular analysis of 28 high- and low-risk HPV genotypes was performed in OOC samples of patients seen during the last 15-years in a Spanish tertiary care center.ResultsOf 115 odontogenic cysts with keratinization, 16 cases of OOCs were confirmed and evaluated. OOCs occurred predominantly in the mandible of males (mean age 36.06 ± 13.16 years). Swelling of the jaw followed by pain were the most common clinical symptoms, and 56.5% of the OOC cases were associated with an unerupted tooth. After a mean post-cystectomy follow-up of 3.8 years, only one recurrent case was observed, resulting in a verrucous cystic lesion that was considered premalignant after immunohistological examination. DNA extraction was successful from 14 of the 16 OOC cases. None of the primary OCCs or the single recurrent OOC were positive for HPV in the molecular analysis.ConclusionsOOCs show a very limited potential for recurrence. Our results suggest that neither high- or low-risk HPV subtypes are likely to play a role in the etiology or neoplastic transformation of OOC, at least in the Spanish population.
Highlights
The role of human papillomavirus (HPV) in orthokeratinized odontogenic cysts (OOCs) has rarely been studied
We evaluated the clinicopathological profile of OOCs seen at our institution over the last 15 years and analysed the possible presence of HPV
The cases were accepted for inclusion as OOC if they fulfilled the criterion of a complete or predominant epithelial lining with non-corrugated orthokeratinization and the presence of a granular layer
Summary
The role of human papillomavirus (HPV) in orthokeratinized odontogenic cysts (OOCs) has rarely been studied. Orthokeratinized odontogenic cyst (OOC) is a rare intraosseous cyst characterized by an orthokeratinized epithelial lining and minimal clinical aggressiveness [1]. OOCs were first described in 1927 by Schultz [2] as a variant of odontogenic keratocysts, known as keratocystic odontogenic tumours (KCOTs) [3]. It was not until 1981 that Wright [4] described their clinicopathological aspects, indicating that OOCs are a distinct entity from odontogenic keratocysts. Over the last two decades, keratinizing cysts from various sites have been evaluated to assess a possible role of human papillomavirus (HPV) in their development and malignant transformation [12]. Reports are available on odontogenic keratocysts [13] as well as carcinoma
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