Abstract
Photodynamic antibacterial therapy shows great potential in bacterial infection and the reactive oxygen species (ROS) production of the photosensitizers is crucial for the therapeutic effect. Introducing heavy atoms is a common strategy to enhance photodynamic performance, while dark toxicity can be induced to impede further clinical application. Herein, a novel halogen-free photosensitizer Aza-BODIPY-BODIPY dyad NDB with an orthogonal molecular configuration was synthesized for photodynamic antibacterial therapy. The absorption and emission peaks of NDB photosensitizer in toluene were observed at 703[Formula: see text]nm and 744[Formula: see text]nm, respectively. The fluorescence (FL) lifetime was measured to be 2.8[Formula: see text]ns in toluene. Under 730 nm laser illumination, the ROS generation capability of NDB was 3-fold higher than that of the commercial ICG. After nanoprecipitation, NDB NPs presented the advantages of high photothermal conversion efficiency (39.1%), good photostability, and excellent biocompatibility. More importantly, in vitro antibacterial assay confirmed that the ROS and the heat generated by NDB NPs could extirpate methicillin-resistant S. aureus effectively upon exposure to 730[Formula: see text]nm laser, suggesting the potential application of NDB NPs in photo-initiated antibacterial therapy.
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