Orthognatic surgery in hemophilia A

Abstract

Hemophilia is a recessive genetic disorder caused by a mutation on the X chromosome, with variable expression. Females are carriers and males express the disease by mother inheritance. This entity consists of a blood coagulation deficiency due to a decrease level of the anti-hemophilic globulin protein (coagulation factor). In hemophilia A the deficiency affects factor VIII in different stages from mild to severe according to the plasma level of the activity of the coagulation factor. Surgical procedures may develop mayor bleeding complications if inadequate preoperative measures take place.