Abstract
The aim of the present study was to explore the effect of oropharyngeal mother’s milk administration on salivary secretory immunoglobulin A (sIgA) levels in preterm infants fed by gastric tube. Infants (n = 130) with birth weight < 1500 g were randomly allocated into two groups which both received breast milk for enteral nutrition. The experimental group (n = 65) accepted oropharyngeal mother’s milk administration before gastric tube feeding for 14 days after birth. The control group (n = 65) accepted oropharyngeal 0.9% normal saline administration. Saliva concentration of sIgA were assessed at the 2 h, 7th and 14th day after birth. The level of salivary sIgA in experimental group were significantly higher than those in control group on the 7th day after birth (p < 0.05), but there were no differences in salivary sIgA levels on the 14th day between the two groups. The results of quantile regression analysis showed that oropharyngeal mother’s milk administration, delivery mode and gestational age had significant effects on the increase of sIgA. SIgA in experimental group and the total number of intervention had a significant positive correlation (p < 0.05). Oropharyngeal mother’s milk administration can improve salivary sIgA levels of preterm infants.
Highlights
The aim of the present study was to explore the effect of oropharyngeal mother’s milk administration on salivary secretory immunoglobulin A levels in preterm infants fed by gastric tube
The oral mucosa of preterm infants fed by gastric tube can not get access to breast milk, there will be a lot of pathogenic bacteria in the oral cavity, which is easy to cause local or systemic infection[13]
The start of oropharyngeal administration in the experimental group was consistent with the beginning of breastfeeding
Summary
The aim of the present study was to explore the effect of oropharyngeal mother’s milk administration on salivary secretory immunoglobulin A (sIgA) levels in preterm infants fed by gastric tube. The experimental group (n = 65) accepted oropharyngeal mother’s milk administration before gastric tube feeding for 14 days after birth. Several studies indicated that nurses could prepare syringe for breast milk instillation or sterile swabs with human milk to wipe the mouth of premature infants[14,15] This intervention is known as Oral Immune Therapy. The purpose of this study was to investigate the effect of oropharyngeal mother’s milk administration on salivary sIgA in preterm infants fed by gastric tube, and to provide a theoretical basis for clinical application
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