Orodispersible Tablets: A Review

Abstract

In the pharmaceutical industry oral route is considered as the safest and convenient route. Orodispersible tablets (ODTs) are solid dosage forms containing drugs that disintegrate in the oral cavity within less than 1 minute leaving an easy to swallow residue. These dosage form contains superdisintegrants which imparts quick disintegration with presence of saliva and can be swallowed easily. ODTs are the very good choice for the pediatric and geriatric patients. To improve the bioavailability of many drugs, orodispersible drug delivery systems are used extensively. Advanced technologies used for manufacturing orodispersible tablets are by direct compression method, freeze drying method, sublimation method, mass extrusion and cotton candy process. Taste is the important factor because these tablets disintegrate directly in the mouth. ODTs are evaluated by following parameters like hardness test, friability test, disintegration test and dissolution test. Many technologies are introduced for producing controlled release orodispersible tablets which broadens the applications of this dosage form. These tablets are also known as mouth dissolving tablets and fast dissolving tablets. In this review article we can focus on ideal properties, challenges, advantages, disadvantages, conventional techniques, patented technologies and evaluation of orodispersible tablets.