Orodispersable Tablets of Salbutamol Suphate using combinational approaches for disintegration: For Effective Management of Asthma

Abstract

Asthma is an inflammatory disorder that results in the obstruction of air pathways and causes difficulty in breathing. Amongst the currently available means of treatment, conventional oral dosage forms are associated with lag time and delayed onset of action. Salbutamol sulphate is a selective β2 receptor agonist widely used as bronchodilator and forms part of initial therapy in chronic as well as acute asthma. In present work an attempt has been made to formulate Orodispersible Tablets (ODT) of salbutamol sulphate by superdisintegrant addition and sublimation technique. ODTs containing subliming material were subjected to drying under vacuum to aid in sublimation and make tablets porous. It was concluded that tablets prepared by addition of sublimation method has less disintegration time than those prepared by superdisintegrantx. These tablets give fast release of salbutamol sulfate which results in fast action in asthmatic attack.