Abstract
Lung cancer is the malignant tumor of highest mortality rate in men worldwide, and its rate is increasing in women. Ornithine decarboxylase (ODC) is the first enzyme in the pathway of polyamines synthesis and its expression was found increased in many types of tumor tissues. This investigation aimed at measuring ODC activity and gene expression in patients with non-small cell lung cancer (NSCLC). 3 different histopathologic types were included; adenocarcinoma (AC), squamous lung carcinoma (SCC) and large cell lung carcinoma (LCC). The patients were at stages I or II and undergone curative tumor resection. The study revealed that, ODC gene expression and activity were significantly elevated in tumor tissue compared to benign tissue (P<0.0001). In tumor tissues from patients with adenocarcinoma and large cell carcinoma ODC had a higher genetic expression level and activity than in tumor tissues from patients with squamous cell carcinoma (P<0.05). We concluded that ODC may have a clinical and prognostic significance regarding the type and severity of tumor in patients with NSCLC.
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