ORMDL3/GSDMB polymorphism and childhood asthma susceptibility: a Meta-analysis

Abstract

Objective To investigate the relationship between ORMDL3/GSDMB polymorphism and genetic susceptibility to childhood asthma. Methods The electronic databases PubMed, Wanfang, China National Knowledge Infrastructure(CNKI), Weipu, and China Biology Medicinedisc (CBM) were browsed for published case-control studies on investigating the association between ORMDL3/GSDMB polymorphism and genetic susceptibility to childhood asthma. Odds ratio(OR) and 95% confidence interval (95%CI) were used to investigate the strength of the association. Fixed or random effect models were selected for pooled OR calculation. Publication bias was assessed. All statistical analysis was conducted with Review Manager 5.0 software. Results Six case-control studies with a total of 3289 childhood asthma cases and 3391 controls were included. For the homozygote TT and T allele carriers (TT+TC), the pooled ORs (95%CI) were 1.86 (1.58-2.20) and 1.56(1.35-1.80)compared to the homozygous genotype (CC). In the stratified analysis by ethnicity, the ORs (95%CI) of the T allele carriers and the homozygote TT were 1.50(1.15-1.96)and 1.51(1.15-1.98)among Asians. While among European, the ORs (95%CI) of the T allele carriers and the homozygote TT were 1.69(1.42-2.02) and 2.11(1.71-2.61). Conclusions ORMDL3/GSDMB polymorphism is overall associated with childhood asthma susceptibility. However, the susceptibility in the Asians is a little lower compared with that of the European populations, which suggest a possible role of ethnic differences in genetic backgrounds. Key words: Asthma; ORMDL3/GSDMB gene; 17q21; Genetic Polymorphism; Meta-analysis; Child