Abstract
Although simple to understand, satisfying to the imagination, and compelling as a teaching aid for beginning students, the evidence is mounting that the tautomeric shift is neither a common nor a likely origin for spontaneous base substitutions. Indeed, other sources, such as ionized base mispairings with nonionized bases, wobble of a bases in the DNA, and transient misalignment of bases causing dislocations at pairing sites, have been shown to induce spontaneous base substitutions. On the other hand, among the 4 common bases in DNA, no experimental evidence exists that tautomeric shifts can induce mutations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
