Abstract
The tryptophan hydroxylase activity and high-affinity uptake of [ 3H]serotonin ([ 3H]5-HT) were measured in five discrete brain regions of rats following lesions of the dorsal or median raphe nuclei. Dorsal raphe lesions reduced enzyme and uptake activity in the striatum only. Median raphe lesions reduced activities in the hippocampus, septal area, frontal cortex, and, to a lesser extent, in the hypothalamus. These data are consistent with the suggestion that the dorsal and median raphe nuclei are the origins of two separate ascending serotonergic systems—one innervating striatal structures and the other mesolimbic structures, predominantly. In addition, our data suggest that measurements of high-affinity uptake of [ 3H]5-HT may be a more reliable index of innervation than either 5-HT content or tryptophan hydroxylase activity.
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