Original two-component fibrin glue preparation technique for use in ophthalmic surgery

Alexey N Kulikov,Anna Yu Kuznetsova,Sergey V Churashov,Ilia O Gavriluk

doi:10.17816/ov15268

Alexey N Kulikov, Anna Yu Kuznetsova + Show 2 more

Open Access

https://doi.org/10.17816/ov15268

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Journal: Ophthalmology Reports	Publication Date: Dec 16, 2019
License type: CC BY 4.0

Affiliation: Kirov Military Medical Academy

Abstract

The study is aimed to modifying the method of a two-component fibrin glue production, as well as studying the possibility of applying glue fixation of the amniotic membrane to the stroma of the cornea, in comparison with interrupted sutures. An experimental study allowed us to determine the optimal composition of the first (base) and second (activating) components, to modify the method for fibrin glue production, and also to test in vivo in six Chinchilla rabbits the fixation of the amniotic membrane using the proposed protocol. The resulting fibrin glue allows not only to securely fix the amniotic membrane to the stroma of the cornea, to reduce the time of the procedure, but also to create conditions for an earlier onset of epithelization while maintaining the transparency of the cornea compared to suture fixation.

Highlights

" Исследование посвящено модификации способа получения двухкомпонентного фибринового клея, а также изучению возможности применения клеевой фиксации амниотической мембраны к строме роговицы в сравнении с узловыми швами
" The study is aimed to modifying the method of a two-component fibrin glue production, as well as studying the possibility of applying glue fixation of the amniotic membrane to the stroma of the cornea, in comparison with interrupted sutures
An experimental study allowed us to determine the optimal composition of the first and second components, to modify the method for fibrin glue production, and to test in vivo in six Chinchilla rabbits the fixation of the amniotic membrane using the proposed protocol

Summary

Introduction

" Исследование посвящено модификации способа получения двухкомпонентного фибринового клея, а также изучению возможности применения клеевой фиксации амниотической мембраны к строме роговицы в сравнении с узловыми швами. Для цитирования: Куликов А.Н., Чурашов С.В., Кузнецова А.Ю., Гаврилюк И.О. Оригинальная методика приготовления двухкомпонентного фибринового клея для применения в офтальмохирургии // Офтальмологические ведомости.

Results

Conclusion