Abstract
Problem The initiation of an immune response often involves the cooperation of various innate immune cells. In the human endometrium, uterine natural killer (uNK) cells and uterine macrophages are present in significant numbers and in close proximity, yet how they cooperatively respond to infectious challenge is poorly understood.Method of study Primary autologous uNK cells and macrophages were co‐cultured to determine functional interactions after stimulation with pathogen‐associated molecular patterns.Results After stimulation by polyI:C, human uNK cells interact with autologous uterine macrophages and produce interferon‐γ in an NKG2D‐dependent manner. Stimulated primary uterine macrophages up‐regulated the expression of MHC Class I chain‐related protein A (MICA), but expression of the cognate receptor NKG2D remained unchanged on uNK cells, even in the presence of cytokines.Conclusion This study demonstrates that the NKG2D‐MICA interaction is an important molecular mechanism that is involved in the innate immune response to microbial signals in the human uterine endometrium.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
